I don't think Apple could add some more protections, they will be skipped sooner or later. Problematic could be programs which using special instructions sets. Intel CPUs have SSSE3 and SSE4, AMD has SSE4a. But if they would use them, the programs wouldn't work on earlier models with older Intel CPUs.

I'm against these clone producers, because they will make OSx86 to a problem for Apple. The people who are buying these computers were potential Apple consumers which are now lost for Apple. I would like to have a kind of OSx86 license. Apple does not develop its own OSx86 and has to give no support. But with this license it's possible to run OSx86 legally on private computers. That would be no big costs for Apple, a sheet of paper with a watermark and a hologram would be enough. And I think the most of the OSx86 users would pay f.e. 120 Euro if they can run their favourite OSx86 legally now. It will still not become a big thread to original Macs or other OS' because of the problematic installation - it's still not as easy as Windows or Linux - and there will be always some restrictions for AMD users.

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2 Opteron systems: OSx86 10.5.8, Andy's 9.8.0 kernel, Asus A8N-SLI Premium, Opteron 185 o'clocked @ 2 x 2,95 GHz (2nd system 2.6 GHz), ATI Radeon HD2600XT 256MB Dual-Monitor 2x HP L2035, 4 GB RAM, Griffin FireWave as main audio device, Marvell + nForce LAN, Asus U3S6 USB3/SATA6 card, 5,5 TB harddisk, Firewire 800 card, Apple Remote + eHome IR receiver, 2x Wacom serial graphics tablet, Canon Pixma iP4700, Logitech Internet Navigator wireless keyboard/mouse combination.

My Audio stuff: M-Audio Transit USB (default audio), M-Audio ProFire 610, M-Audio ProFire Lightbridge (34 channels) using Creamware A16 ADAT converter • MIDI: M-Audio Midiman 4x MIDI interface • Behringer Audio Mixers: Xenyx 1002, Xenyx 1002FX, Xenyx 1202FX, Eurorack UB1002FX, Eurorack MX1804FX, Eurorack MX262A • FX devices: Lexicon MPX100 DSP, Behringer DSP-1000 Virtualizer, Behringer MiniFEX 800 DSP, Behringer Multicom Pro MDX4400 compressor • RETRO: MSSIAH midi/sequencer/synthesizer cardridge for the C64 (Dual-SID), Steinberg M.S.I. MIDI Interface for C64