Have you perused Project Snow? The author uses a EP45T-UD3P and provides detailed instructions on installation.

I've a EP45-UD3P with a Q6600. SL runs on all of four kexts and a modded DSDT, though I do have issues thanks to my Sapphire 3870.

This board, (the UD3P), accommodates SL quite gracefully.

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q6600 @ 3.6 gHz (In Leopard) (9 x 400)
ep45-UD3P ver. 1.0, bios F10e (1.20 ahci)
Sapphire 3870
4 gigs 1066 Reaper
8 x WD 250 YD-01NVB1
800w BFG ES
Xig S1283
20" $10 Box Fan & a deconstructed P2 case with the side removed.