After waking up from sleep, beachball appears and am unable to force quit (10.5.2 Rev.2)

[WinLinMac01]

Problem: When I woke my system up from sleep mode, I clicked on the Safari icon. A few seconds later the beachball appeared and I had no choice but to improperly restart my system because I wasn't able to force quit the application. I also tried to do the same with another application, and the same result appeared. I can move my mouse anywhere, but when clicking on a folder or application, after a few seconds, problems appear. This only occurs after waking up my system from sleep. Can someone explain why this is happening. I wouldn't really consider waking up my system from sleep mode. Instead, it is my monitor that really falls to sleep. Any support would be very kindly appreciate. Thank you all in advance. Below are my specifications-

Processor/CPU2.26 GHz AMD Athlon™ 64 Processor 3500+ Venice
MotherboardGigabyte Technology K8NXP-SLI---Nforce 4 SLI Chipset
Memory/RAM3 GB 400 MHz DDR SDRAM PC3200, 2xCorsair XMS (2GB), 2xCrucial Ballistix (1024MB)
Hard Drive(s)1 SATA2, 320GB, Western Digital, 16MB Cache
Other Device Info1 NU IDE/PATA DVD-RW, 16x, 1.44"-inch NEC Floppy Disk Drive
Video Card/GraphicsNvidia Geforce 6600GT 128MB PCI Express (2) / SLI-mode [QE/CI Enabled]
Audio InterfaceAC'97 8-Channel/16-bit
LAN Interface(s)NVIDIA/Marvell/Realtek
Keyboard/Mouse ComboLogitech LX700 Cordless Desktop
Monitor/DisplaySamsung SyncMaster 216BW Series
PrinterCanon PIXMA MP830 (Latest)
Router ConnectivityNetGear RangeMAX WPN824, Version 2.
Operating Systems(1). Windows Vista x86 Ultimate [Retail], (2). Mac OSX Leopard 10.5.2, (3). Sabayon Linux (Stable)

[WinLinMac01]

Any help would be appreciated, thanks.

[R0GUE]

Do you have "put the hard disk(s) to sleep when possible" option checked? If so, uncheck it and your system will resume as normal.

[WinLinMac01]

Thanks got that working. Do you know how I can install Windows Vista and Leopard on the SAME hard drive. I created one NTFS partition for Vista (MBR) and one HFS+ Extended Journal Partition for Leopard with MBR as well. I selected the dual bootloader option in Zephyroth's release, but after install is completed, I get the following message: "Missing OS" (after restart). What should I do? Please let me know. Thanks.