Ive done it with no problem. i have an amd dual core 64 bit 6000+ it runs at 3.1ghz. i didnt have to do anything special i just installed it and it works fine. I am running virtual systems of windows 98 windows xp windows vista 64 bit and windows 7 64 bit. the only problem i have is that it doesnt recognize my graphics card but i think that is an issue with using an ATI cards for osx86 and i am using the voodoo kernel