@Voyn1x: Been there man, pretty much everything on the old mouse bug thread, I've tried.

http://www.infinitemac.com/comments.php?DiscussionID=753&page=14#Item_11

Still stuck with the problem, everything seems to have some kinda effect, longer/shorter uptime, but nothing seems to have fixed it.

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My Hackintosh:
Kalyway 10.5.2 Intel/Amd -- Speedstep, Netkas Smbios, AMD test patch 2.
Mobo: MSI K9AGM2
Chipset: AMD 690v ATISB600 -- SB600ATA kexts
CPU: 3Ghz AMD Athlon 64x2 6000+
Ram: 2gb Rambo DDRii 667
Graphics: Nvidea MSI nx8600GT 512MB -- NvInject 512 (fully supported 100% working)
Audio~External: Focusrite Saffire -- (100% working - ootb)
Ethernet: 8101E -- Realtek R1000 (100% working)
HDD: 320GB WD SataII (150gb Boot Partition)
150gb Lacie Firewire/USB RIP my dear Lacie.