The only definite way to force the cache to be rebuilt which I have seen documented on apple is the touch command. Though deleting it will obviously do the same. I have used the -f flag in the past and it seems to work but I never saw it documented on the site. I have adopted a redundancy approach as it should 100% ensure the cache is rebuilt. I use both the touch command, removing of the actual cache file and the -f boot-flag.
Just as lawless mentioned the -f boot-flag will force OSX to pull kexts from the Extensions folder and not the cache file. There is also a -F (note the caps) boot-flag which forces OSX to ignore the com.apple.boot.plist which contains boot preferences. Though if you cant even boot I doubt it will matter.

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