Usually when there is a lot of harddrive thrashing my mouse movement gets glitchy as heck and jumpy. ie. when Transmission is checking a file or something. I am using Zephs 10.5.2 v1 install and the new speedstep 9.2.0 kernel.

AMD Opteron 165 (Dual Core)
DFI Ultra-D nForce4 Ultra
G.Skill 2gb RAM
eVGA Geforce 6800GS (QE/CI)
Buffalo WiFi (Broadcom chipset)
WD 120gb SATA (Leopard)
WD 250gb SATA (Time Machine)
WD 250gb SATA (Windows XP)
WD 500gb SATA (Files)

All users with this problem, please go to this thread and discuss there:
<a href="http://osx.kbot.de/comments.php?DiscussionID=753">http://osx.kbot.de/comments.php?DiscussionID=753</a>