Nope you don't need another partition, you can do it fine from safe mode.

First create your patcher package using Marvins and copy it to the root of your drive. Reboot, press F8 while booting and then type:

If you're refering to the AMD Patcher which Zeph has just released for beta testing, it checks install packages for CPUIDs and patches them so that they will operate on your AMD system.