i've start to fiddle arround with some bios settings... maybe there are some options to solve that kind of problem!

changed:
disable: CnQ
memory CL timings raised from CL5 to CL6
Disabled some ACPI settings
Disabled Enhanced halt state
Disabled Advanced Virtual Machine
Disabled USB Legacy Mode
Disabled PCI Busmaster

leopard is working fine atm since 2 hours no crashes no mousejumps, i will report if the issue happens again!

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HomeHackintosh:
AMD Athlon64 X2 4400 :: ASRock ALiveNF5-eSATA2+ R3.0 :: Corsair 2GB DDR2-800 :: Gainward Geforce 8800GS PCI-E :: Maxtor 250GB SATA HD :: Audiotrak Maya 44 USB :: Phillips 22" 220AV TFT ::
Custom 10.5.5 Voodoo_Beta2 Kernel

Minimacbook:
Acer Aspire One A150X Netbook :: Intel Atom 1,6Ghz :: 1GB DDR2 :: Seagate 120GB SATA HD :: Acer 8,9" Crystal Bright TFT ::MSI Wind OSX 10.5.4 upgraded to 10.5.5 & Voodoo_Beta2 Kernel