i had the same problem, never knew what was wrong. it was a problem with a dodgy soundcard kext, i found the only way to fix it was pause itunes close whatever program you have open other then itunes and click on the desktop and toggle the sound on and off via a mute button or sound up button on the keyboard until you hear something come out again. and it seems to only happen when you pause the tracks so from now on dont pause, just mute. annoying i know but i couldnt find any fix for it. what soundcard do you have? i think i had an ALC850 card...now im running on a motherboard on a retail install so im all laughs

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iMac ::: Mac OS X 10.6.1 ::: Intel Core2Duo 2.93GHz ::: NVIDIA Geforce GT 120 256MB ::: 4GB DDR3 RAM

Milanca Project ::: Mac OS X 10.6.1 Retail ::: Vanilla Kernel ::: Intel Core2Quad Q6600 2.4GHz ::: NVIDIA GeForce 8600 GT 256MB ::: 4GB DDR2 RAM ::: GIGABYTE GA-EP35C-DS3R